Abstract
Septal-lesioned rats and unoperated controls were tested for acquisition of a shuttlebox avoidance task. Each animal received either a 105-mg/kg 5-hydroxytryptophan (5-HTP) or a saline injection prior to each day’s testing. Septal animals with saline injections were significantly faster in learning the task. This facilitation was significantly attenuated by injections of 5-HTP. The data suggest that septal lesion-induced shuttlebox facilitation may be a function of the serotonin reduction previously reported to be a consequence of the lesion.
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