Abstract
ABSTRACTBackground: Isomaltodextrin (IMD) is a novel highly branched α-glucan and its function as a soluble dietary fiber is expected.Objective: The goal of this study was to evaluate the effects of IMD on postprandial glucose excursions in healthy people and to make the mechanism clear.Design: Twenty-nine subjects ingested a solution containing maltodextrin (MD) or sucrose with or without IMD. Fourteen subjects ingested a solution containing glucose with or without IMD. Blood glucose concentrations were then compared between the groups. Furthermore, in vitro digestion, inhibition of digestive enzymes, and glucose absorption tests were conducted.Results: IMD attenuated blood glucose elevation in the subjects with blood glucose excursions at the high end of normal following the ingestion of MD or sucrose or glucose alone. This effect of 5 g IMD was most clear. IMD was digested partially only by small intestinal mucosal enzymes, and maltase and isomaltase activities were weakly inhibited. Furthermore, IMD inhibited the transport of glucose from mucosal side to serosal side.Conclusions: IMD attenuated postprandial blood glucose, after the ingestion of MD or sucrose or glucose. As one of the mechanism, it was suggested that IMD inhibited the absorption of glucose on small intestinal mucosal membrane.
Highlights
Isomaltodextrin (IMD) is a novel highly branched α-glucan and its function as a soluble dietary fiber is expected
Isomaltodextrin (IMD) is a novel highly branched αglucan produced enzymatically from starch using αglucosyltransferase and α-amylase derived from Paenibacillus alginolyticus PP710 [1]
Resistant maltodextrin (RMD) and polydextrose are recognized as glucose-based soluble dietary fibers, but IMD is different in that it consists of only α glucosidic linkage and has many α-1,6 glucosidic linkages compared with these materials
Summary
Isomaltodextrin (IMD) is a novel highly branched α-glucan and its function as a soluble dietary fiber is expected. Design: Twenty-nine subjects ingested a solution containing maltodextrin (MD) or sucrose with or without IMD. Results: IMD attenuated blood glucose elevation in the subjects with blood glucose excursions at the high end of normal following the ingestion of MD or sucrose or glucose alone. This effect of 5 g IMD was most clear. Resistant maltodextrin (RMD) and polydextrose are recognized as glucose-based soluble dietary fibers, but IMD is different in that it consists of only α glucosidic linkage and has many α-1,6 glucosidic linkages compared with these materials.
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