Abstract
Attenuation of Oxidative Enzymes Induction in Palm Oil Fractions Pre-treated Cadmium Intoxicated Rats
Highlights
The use of cadmium for electroplating in most industries makes it one of the elements that come in regular contact with man
Oxidative enzymes (AO and sulphite oxidase (SO)) have been identified as cytosolic enzymes which are absolutely necessary in the breakdown of a number of aldehydes, nitrogenous heterocyclic compounds and endogenous sulphites
Based on the earlier stated roles of aldehyde oxidase (AO) and SO in xenobiotic metabolism, there is no doubt that the observed increase of tissue and serum AO and SO after cadmium administration may be traceable to the activation of synthesis of these enzymes in order to clear or minimize the tissue levels of aldehydes, sulfoxides, N-oxides and aromatic oxides
Summary
The use of cadmium for electroplating in most industries makes it one of the elements that come in regular contact with man In metallurgy, it is used for brazing and soldering of alloys. The study of Achuba and Ogwumu[18] revealed that palm oil can confer protection against haematotoxicity in rats that were fed diesel contaminated diets With these pieces of evidence, and the knowledge of the high level of antioxidants in crude palm oil and palm oil extracts it has been adjudged as an effective natural product for the protection against cadmium poisoning this study investigated the ability of palm oil and its extracts to confer protection against the induction of aldehyde and sulphite oxidase enzymes in acute cadmium intoxication
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