Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E

Abstract

The aim of this research was to study the consequences of ω3 fatty acids (FA) administration around calving on inflammatory response and on productive performances. In this period dairy cows undergo a metabolic challenge, coming with an inflammatory-like status triggering the release of pro-inflammatory mediators (e.g. eicosanoids, cytokines). Eicosanoids synthesis may be modulated by altering the ratio of their precursors (ω3 and ω6 FA). Ten cows received 22 g/d of rumenprotected ω3 FA from −21 to +21 days from calving (OPT), while 10 (CTR) received no supplement. Cows were frequently monitored for health status, body condition score (BCS), blood (metabolic, inflammatory and FA profiles), milk yield. OPT (vs CTR) showed a similar milk production, a numerically smaller BCS drop, lower postpartum levels of nonesterified fatty acids (P<0.05), β-hydroxybutyric acid (P<0.1) and creatinine (P<0.05), suggesting a milder post-calving reserves mobilization. All cows underwent an inflammatory condition around calving, but OPT showed a milder response, as suggested by lower levels of bilirubin (P<0.05), and by the higher level of Liver Functionality Index (P<0.10). Plasma concentration of ω3 FA (eicosapentaenoic and docosahexaenoic acids) increased in OPT during treatment (P<0.01 vs CTR). Since ω3 FA are the main replacers of arachidonic acid in membrane phospholipids, their increased levels in plasma of OPT cows may have cut the formation of arachidonic-derivatives (pro-inflammatory mediators), countering the beginning of the inflammation. Hence, the administration of rumen-protected ω3 FA in transition period seems to attenuate the effects of subclinical inflammations and to improve the energy balance.