Abstract
Several experiments show that spontaneously hypertensive rats (SHR) are behaviorally hyperactive when compared with their normotensive Wistar Kyoto (WKY) progenitor rat strain. Behavioral hyperactivity was present in both 3-min open-field tests as well as in 1-hr tests using an automated activity recording chamber. In addition, under certain conditions, d-amphetamine (1.25–3.5 mg/kg) decreased activity in the SHR while inducing the expected increase in activity in the WKY. Further analysis of these data shows that the attenuation of SHR behavioral hyperactivity by amphetamine can be predicted based upon rate dependency of the actions of d-amphetamine. The SHR may provide a valuable animal model for studying spontaneous hyperactivity and for investigating the neurochemical basis of the so-called “paradoxical response” to amphetamine as seen in children.
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