Abstract
Adult male Wistar rats ( n = 21) received bilateral kainic acid lesions of their hippocampi. Over a period of 9 weeks the animals received daily IP injections of either 5 μg/kg or 50 μg/kg substance P (SP) or vehicle. Seizures provoked by the lesions were suppressed by the daily administration of the neuropeptide SP in a dose of 50 μg/kg for the whole period of observation. The neurokinin significantly ( p < 0.01) reduced the number of seizures compared to the vehicle-treated animals.
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