Attenuation of haemodynamic response to laryngoscopy and endotracheal intubation a comparative study between I.V. labetalol and I.V. lignocaine

Abstract

One of the most common procedures performed by the anaesthisiologists is the Endotracheal Intubation. During this procedure, hemodynamic changes, which may be rapid and dramatic and adverse to the patient may occur. Lignocaine is an excellent drug for the attenuation of pressor events and Labetalol is a potent antihypertensive drug. 50 patients between the ages 18 to 60 years who were scheduled for various procedures under general anaesthesia with ASA Grade I status were included into the study and divided into 2 groups of 25 each. One group was given intravenous Labetalol 0.75mg/kg 10 minutes before intubation and the other group received intravenous injection of Lignocaine hydrochloride (without preservative) 2% in a dose of 1.5 mg/kg over a period of 10 seconds, before 90 seconds of laryngoscopy and intubation. The parameters were lower in Labetalol group (P<0.05) compared to the lignocaine group. The arterial pressures in the Labetalol group attained basal value, and heart rate nearing basal value. The arterial pressures in the Lignocaine group were slightly higher a than basal values and the heart rate is higher than baseline value.Labetalol given intravenous was more advantageous compared to other methods for attenution of hemodynamic changes after laryngoscopy and intubation as it has a good attenuation of pressor response and heart rate and provides a good intra operative profession against haemodynamics response to surgical stimuli.