Abstract
BackgroundHemodynamic changes and respiratory tract complications are often followed by tracheal extubation. These events may be dangerous in neurosurgical patients and those with cardiovascular disease or at an old age.ObjectivesThe aim of this study is to investigate the attenuation of cardiovascular responses and upper airway events resulting from tracheal extubation by low dose propofol.Materials and Methods80 patients with ASA physical status I, undergoing an elective surgery in a double blind manner received 0.5mg/kg propofol or normal saline 2 minutes before extubation. Heart rate and blood pressure and quality of tracheal extubation were recorded.ResultsHeart rate and blood pressure in patients receiving propofol were less than the control group (P < 0.05) at the time of injection of propofol, but there were no differences between the two groups at the time of extubation.ConclusionsWe concluded that propofol can reduce SBP, DBP, MAP, HR & cough production at the time of injection but there were no significant changes in these parameters after extubation.
Highlights
Hemodynamic changes and respiratory tract complications are often followed by tracheal extubation
Implication for health policy/practice/research/medical education: This is a study on attenuation of cardiovascular responses and upper airway events to tracheal extubation by low dose propofol
The mechanisms of increasing heart rate and blood pressure during and after tracheal extubation have not been certainly determined, yet these changes may be associated with the release of cathecholamines
Summary
Hemodynamic changes and respiratory tract complications are often followed by tracheal extubation. These events may be dangerous in neurosurgical patients and those with cardiovascular disease or at an old age. Objectives: The aim of this study is to investigate the attenuation of cardiovascular responses and upper airway events resulting from tracheal extubation by low dose propofol. Heart rate and blood pressure and quality of tracheal extubation were recorded. Results: Heart rate and blood pressure in patients receiving propofol were less than the control group (P < 0.05) at the time of injection of propofol, but there were no differences between the two groups at the time of extubation. Tracheal extubation is often accompanied by significant hemodynamic changes and respiratory tract complications [1]. A variety of drugs such as esmolol, alfentanil, diltiazem, verapamil, fentanyl and lidocaine have been used to control hemodynamic changes and upper airway tract events [4,5,6]
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