Abstract
Rats with lesions of the area postrema/immediately adjacent nucleus of the solitary tract (AP/mNTS-lesions) have an attenuated feeding response after several manipulations that induce food intake in intact control rats. In this study we examined the ingestive response of rats with AP/mNTS-lesions after treatment with 8-OH-DPAT, a 5-HT 1A agonist. Rats with AP/mNTS-lesions failed to increase their food intake after treatment with 8-OH-DPAT at doses that stimulated food intake in intact rats. These data suggest that altered serotonergic function may contribute to the attenuation of feeding observed in rats with AP/mNTS-lesions after treatment with some orexigenic stimuli.
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