Abstract

In this study, we demonstrated that the fermentation of Armillaria luteo-virens with Lactobacillus delbrueckii subsp. bulgaricus has a protective effect on human skin fibroblasts (HSFs) irradiated by UVA. We studied the fermentation broth of Armillaria luteo-virens (FBA) at the structural, cellular and genetic levels, and found that the content of polysaccharides in FBA increased, and the molecular weight of polysaccharides decreased by fermentation. After FBA pretreatment, we irradiated the cells with UVA, and found that the antioxidant capacity of the cells was significantly enhanced, and the activity of mitogen activated protein kinase (MAPK) pathway induced by UVA was weakened. The secretion of tissue inhibitory metalloproteinases (TIMPs) was inhibited, which decreased the activity of matrix metalloproteinases (MMPs) and increased the content of type I collagen (COL-I). Experiments have proved that FBA can enhance the antioxidant capacity and reduce the oxidative stress caused by UVA irradiation, giving it prevention potential against the photoaging process.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.