Abstract
The effects of aging on the stress response of the septo-hippocampal cholinergic neurons was assessed by monitoring hippocampal acetylcholine (ACh) release. Young (3–4 month old) and aged (23–24 month old) male rats were subjected to restraint stress for 1 h. ACh was elevated within 15 min of the onset of restraint stress (177.5% of basal level) in young rats but not in aged rats. Corticosterone concentration was significantly elevated by restraint stress in young rats but not in aged rats. The present results suggest that stress response of the septo-hippocampal cholinergic neurons and the hypothalamic-pituitary-adrenocortical axis is attenuated during aging.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
