Abstract

As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the most important parts of the Toxicological Profile for Chlorinated Dibenzo- p-dioxins (CDDs) [ATSDR. Toxicological profile for chlorinated dibenzo-dioxins (CDDs). Agency for Toxic Substances and Disease Registry, Atlanta, GA, 1998] into the scientific literature. Toxicological information includes health effects, toxicokinetics, mechanism of toxicity, biomarkers, interactions, and evaluation of animal to human extrapolation of data. Environmental information encompasses chemical and physical properties, potential for human exposure, and a listing of regulations and advisories. Because of the enormous database for CDDs, this particular toxicological profile is unusually long. Therefore, the profile had to be substantially shortened for the purpose of this article. Interested readers are encouraged to consult the original toxicological profile for more information. All original profiles can be requested from ATSDR's Information Center by telephone (1-888-42-ATSDR [1-888-422-8731] or E-mail: (atsdric@cdc.gov).

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