Abstract
AbstractA series of enantioenriched substituted tetrahydropyrrolo[3,2‐c]azepine products possessing an axial chirality were synthesized in 63–99% yield through a gold(I)‐catalyzed hydroarylation. DFT calculations rationalized the reactivity observed for the formation of such complex molecular frameworks and guided our choice in the pyrrole N‐substituent to isolate configurationally stable compounds.magnified image
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