Atropisomeric carbamoyl type inhibitors of pancreatic cholesterol esterase

Abstract

Atropisomers of 1,1′-bi-2-naphthyl-2,2′-di- N-butylcarbamate ( 1), 1,1′-bi-2-naphthyl-2- N-butylcarbamate-2′-ol ( 2), and 1,1′-bi-2-naphthyl-2- N-butylcarbamate-2′-butyrate ( 3) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (K I), the carbamylation constant (k 2), and the bimolecular rate constant (k i).