Abstract
The Patching Versus Atropine Trial was a randomized clinical trial in children less than seven years of age with moderate amblyopia and a visual acuity in the amblyopic eye between 20/40 and 20/100, to determine whether treatment with atropine drops was as effective as patching. The study found that patching and atropine were equally effective in the initial treatment of moderate amblyopia. Visual acuity in the amblyopic eye improved in both groups (improvement from baseline to 6 months was 3.16 lines in the patching group and 2.84 lines in the atropine group). Improvement was initially faster in the patching group, but, after 6 months, the difference in visual acuity between treatment groups was small and clinically inconsequential (mean difference at 6 months, 0.034 logMAR units).
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