Abstract
Effects of local administration of atropine into the medial septal nucleus (MSN) and dorsal septal nucleus (DSN) were tested in laboratory rats. Atropine administration led to the development of a spike/wave activity in the hippocampus as well as amygdala within 10 minutes. The frequency of spikes ranged in the absolute values from 20 to 25 spikes per minute in the case of atropine administration to MSN, while in the case of DSN it reached only about 16 spikes per minute. Spike/wave activity outlasted in the EEG record within 2 hours. The average incidence of spikes was somewhat lower in females than in males. A possible relation of the atropine-induced spike/wave activity to another kinds of limbic convulsions is discussed.
Highlights
The septum, the septohippocampal system, represents an important part of the limbic system
A typical example represents the production of 4 to 12 Hz activity - the „theta“ rhythm [5].The medial septal nucleus (MSN) and the dorsal septal nucleus (DSN) - it is called the nucleus of the diagonal band of Broca- are known to be the principal sources of cholinergic input to the hippocampal formation [10,16]
By means of the local lesion strategy, the existence of some heterogenity within MSN and DSN
Summary
The septum, the septohippocampal system, represents an important part of the limbic system. A typical example represents the production of 4 to 12 Hz activity - the „theta“ rhythm [5].The medial septal nucleus (MSN) and the dorsal septal nucleus (DSN) - it is called the nucleus of the diagonal band of Broca- are known to be the principal sources of cholinergic input to the hippocampal formation [10,16]. DSN is oriented most likely toward the limbic lobe and neocortical structures, while MSN is connected with the hippocampal and amygdala region. Confirmation of this conclusion was based on the different changes in AChE activity following lesions of MSN and DSN [7]. We have provided additional evidence in this context in pharmacological experiments [9]
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