Abstract
PurposeOsteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age.Subjects and MethodsA total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized.ResultsThe proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11).ConclusionsAtrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.
Highlights
Osteoporosis is a metabolic bone disease characterized by the decrease in bone mass with microarchitectual disruption and enhanced skeletal fragility, resulting in an increase for fracture risk [1]
A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001)
A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status
Summary
Osteoporosis is a metabolic bone disease characterized by the decrease in bone mass with microarchitectual disruption and enhanced skeletal fragility, resulting in an increase for fracture risk [1]. Conditions causing a decrease in gastric acid secretion status, including gastric surgery, and use of proton pump inhibitors increase the risk for low bone mass or fractures [10,11]. Atrophic gastritis, another hypochlorhydric condition, can adversely affect bone mineral density; studies about atrophic gastritis and bone mineral density are sparse and inconclusive [12,13]
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