Abstract
Homeostatic regulation of fluid and electrolyte balance is essential for survival. The kidney plays a primary role in determining the composition and volume of body fluids. Although numerous factors which regulate this homeostatic balance have been analysed, the humoral control of sodium excretion has been elusive. In this review Philip Needleman and his colleagues deal with the very recent identification of a novel family of peptides - atriopeptins I, II and III - present in the heart that have the capacity to modulate renal and vascular function. They also discuss the future.
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