Abstract
Objective. Atrial Natriuretic Peptide (ANP) has natriuretic and diuretic effects, synthesized and stored in the atrial cells, released in response to stretch of the atrial muscle during increase venous return. Acute gastroenteritis (AGE) causes dehydration. We intend to determine whether the decrease in venous return due to dehydration would lead to a decrease in ANP levels. Patients and Methods. This is a prospective observational controlled study. Blood collected from 30 children with AGE and ANP's levels were compared with 25 controls. ANP levels were determined by radioimmunoassay. Results. The study group was in mild dehydration. As a significant difference was found in ANP levels between children in the 3mo–3y group and older children 3y–14y. We analyzed the results according to age. No difference was found between children with AGE and control, in the 3mo–3y, ANP was 12.1 ± 11 pg/ml versus 13.4 ± 12 pg/ml respectively, and 3 ± 2 versus 3.8 ± 3 pg/ml in the 3y–14y groups, respectively. Conclusion. Dehydration due to AGE does not change the ANP's plasma levels. A weak positive correlation between sodium levels and ANP was found r = 0.29. The significant finding of our study is the difference in ANP levels related to age, in the control as well as the GE group.
Highlights
Atrial natriuretic peptide (ANP), a member of the family of natriuretic peptides, regulates a variety of physiological parameters including diuresis and natriuresis
The relation between plasma volume and ANP levels were examined in many studies: [8] An increase in the plasma volume through intravenous infusion of Mannitol or saline causes an increase in the ANP levels [9]
It is known that in pathological situations in which there is an increase in plasma volume, such as heart failure, pneumonia or SIADH, there is an increase in plasma ANP levels [10,11,12,13]
Summary
Atrial natriuretic peptide (ANP), a member of the family of natriuretic peptides, regulates a variety of physiological parameters including diuresis and natriuresis. It is synthesized in and secreted from cardiac atria. Research examining the distribution of ANP and its receptors in the digestive system pointed to their presence in the human’s stomach, intestines, and colon. These findings raised the question on ANP’s function in physiological and pathological situations in the digestive system; most of the studies were conducted on mammals and indicated that
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