ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

Abstract

(Molecular Cell 60, 35–46; October 1, 2015) In the above article, the description for Figure 4C was incorrect in the legend. The first sentence of the figure legend was inadvertently written as “Phosphorylation of ATR at S428 is needed for ATR-Bid interaction” and should read “Absence of phosphorylation of ATR at S428 is needed for ATR-Bid interaction.” The authors regret this error, which has been corrected in the online version. ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1Hilton et al.Molecular CellSeptember 17, 2015In BriefDNA damage response regulator ATR is implicated in strategies for cancer prevention and treatment, but the mechanisms remain unclear. Hilton et al. report that besides its hallmark nuclear functions, cytoplasmic ATR is Pin1 regulated, and the cis-isomeric ATR has a direct antiapoptotic role at mitochondria via a BH3 domain after UV damage. Full-Text PDF Open Archive