Abstract

BackgroundPatients with diabetes mellitus were often accompanied with hyperlipidemia. ATP-binding cassette sub-family A member1 (ABCA1) promotes the efflux of lipids and thereby mediates the metabolism of cholesterol. The aim of our study was to determine the associations of ABCA1 gene polymorphisms with the risks of diabetes mellitus and dyslipidemia in diabetic patients.MethodsWe retrieved literature about the relationship between ABCA1 gene polymorphisms (C69T and R230C) and the risk of diabetes through PubMed, Web of Science, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Cochrane database. Weighted mean difference (WMD) and odds ratio (OR) were used to compare continuous and dichotomous variables, respectively, accompanied by their 95% confidence interval (CI).ResultsA total of 1746 diabetic patients and 1292 non-diabetic controls were enrolled. All subjects were Caucasians. ABCA1 R230C T allele was significantly associated with reduced the risk of diabetes (OR = 0.75, 95% CI = 0.57–0.98, P = 0.04). There was no association of ABCA1 C69T gene polymorphisms with the risk of diabetes. However, subgroup analyses showed that the ABCA1 C69T gene mutation significantly reduced the risk of hypertriglyceridemia in diabetic patients as compared with that in non-diabetic subjects (dominant model: WMD =0.66, 95% CI = 0.52–0.8, P < 0.0001; recessive model: WMD = 0.47, 95%CI = 0.11–0.83, P = 0.01).ConclusionsABCA1 R230C T allele gene mutation is a protective in decreasing the risk of diabetes in Caucasians and ABCA1 C69T gene mutation markedly influences the level of lipid metabolism in diabetic patients.

Highlights

  • Patients with diabetes mellitus were often accompanied with hyperlipidemia

  • Compared with the control group, the ATP-binding cassette sub-family A member1 (ABCA1) C69T gene mutation significantly reduced the risk of hypertriglyceridemia in diabetic patients

  • The results showed that the ABCA1 R230C T allele was significantly decreased in the diabetic patients than that in the non-diabetic subjects (OR = 0.75, 95% confidence interval (CI) = 0.57–0.98, P = 0.04, Additional file 3: Figure S3)

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Summary

Introduction

Patients with diabetes mellitus were often accompanied with hyperlipidemia. ATP-binding cassette sub-family A member (ABCA1) promotes the efflux of lipids and thereby mediates the metabolism of cholesterol. The aim of our study was to determine the associations of ABCA1 gene polymorphisms with the risks of diabetes mellitus and dyslipidemia in diabetic patients. Hyperlipidemia, environmental and genetic factors, the major risk factors for the occurrence of DM, are always considered as the important research content of diabetes etiology [3, 4]. ATP-binding cassette sub-family A member 1 (ABCA1), a highly conserved transmembrane protein, is abundantly expressed on the plasma membrane and Golgi complex [5,6,7].

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