Abstract
The lymphocyte ATP-ase activity was significantly elevated in three groups of cancer patients compared to the activity of lymphocytes from normal individuals and patients with various nonmalignant diseases. Oligomycin inhibited and 2, 4 dinitrophenol stimulated the ATP-ase activity of the lymphocytes from both groups, indicating a contribution of the mitochondrial ATP-ase. Incubation of normal lymphocytes with phytohemagglutinin in vitro increased the oligomycin-sensitive ATP-ase activity of the cells considerably. It is suggested that the significantly elevated ATP-ase activity of lymphocytes from cancer patients is probably due to an in vivo stimulation following a reaction between lymphocytes and tumor antigens.
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