Abstract
THE PRODUCTION of abnormally discharging cortical foci in experimental animals provides a model having some resemblance to human focal epilepsy. Local cortical freezing is one of several procedures which have been effective in producing epileptogenic lesions. Nims et al employed an ethyl chloride spray to produce a freezing cortical lesion, 1 and more recently Morrell et al have described in detail results with the same method. 2 Although the rat has been said to be relatively resistant to cortical freezing, 3 Morrell's technique has proved effective in inducing abnormally discharging lesions in this animal, and experience with the rat will be described. Such lesions should be useful for investigating chemical alterations associated with the resulting electroencephalographic abnormality. The ATPase requiring Na + and K + as well as Mg ++ for full activation (Na-K-ATPase) was selected for study because of the suggested association of this enzyme with transport of Na + and K
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.