ATP Synthesis and the Binding Change Mechanism: the Work of Paul D. Boyer

Robert L Hill,Nicole Kresge,Robert D Simoni

doi:10.1016/s0021-9258(20)55940-1

Abstract

ATP Synthesis and the Binding Change Mechanism: the Work of Paul D. Boyer

Highlights

Paul Delos Boyer was born in 1918 in Provo, Utah
Boyer focused on finding a possible phosphorylated intermediate in ATP synthesis using 32P as a probe. This culminated in the discovery of a new type of phosphorylated protein, a catalytic intermediate in ATP formation with a phosphoryl group attached to a histidine residue. He later found that the enzyme was an intermediate in the substrate level phosphorylation of the citric acid cycle and not a key to oxidative phosphorylation
In the summer of 1963, Boyer moved his laboratory to the Department of Chemistry and Biochemistry at the University of California in Los Angeles, where he remains today as Professor Emeritus. He became the Founding Director of the Molecular Biology Institute at UCLA in 1965 and spearheaded the construction of the building and the organization of an interdepartmental Ph.D. program. This institutional service did not diminish his research program, and he continued to focus on oxidative phosphorylation

Summary

Introduction

Paul Delos Boyer was born in 1918 in Provo, Utah. He attended Brigham Young University where he focused on chemistry and mathematics. After receiving his B.S. degree in chemistry in 1939, Boyer set off for the biochemistry department at the University of Wisconsin in Madison. Boyer was granted his Ph.D. in 1943 and headed to Stanford University to work on a war-related research project dedicated to the stabilization of serum albumin for transfusions. With the completion of the project in 1945, Boyer accepted an offer of an Assistant Professorship at the University of Minnesota.

Results

Conclusion