Abstract
Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Since ATP is the major energy currency in all living cells, its synthesis and function have widely been studied over the last few decades uncovering several aspects of ATP synthase. This review intends to summarize the structure, function and inhibition of the ATP synthase.
Highlights
Introduction results inATP synthesis and breakdown, and allows for signaling functions that have a uniquely broad facilitates electron transport
This pioneered the research on the coupling of the electron transport chain (ETC) and ATP synthesis
It is well established that the electrochemical potential of protons delivered by electron transfer chains across the mitochondrial, chloroplast or bacterial membrane provides the energy for ATP synthesis [14]
Summary
Prashant Neupane*, Sudina Bhuju, Nita TRheacepivae,dHMiatye8s,h20K18u;macacerpBtehdaStetpatreamiber 22, 2018. There exists an automorphism of the endomorphism algebra of V that swaps is uniquepA,hDaoPnscpdahncaataelbl(sePodir)b,thaelenoendrgugyawlaiitnthydcAroeng↔saiidnAetr∗ha.ebIlgnerorteuhlpeeatposerreeosgfeeennnteerpragatyep. er we give a c
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