Abstract
ATP-gated P2X receptors in health and disease.
Highlights
This collection is devoted to the role of extracellular adenosine 5 triphosphate (ATP) as a physiological transmitter in health and as an essential contributor to various pathologies
A further fundamental role of adenosine triphosphate (ATP) was later identified, namely that extracellular ATP serves as a messenger for fast intercellular communications via binding to and activation of a set of membrane proteins termed P2X receptors
ATP-gated P2X receptors are expressed in neurons, glia and vascular cells and are characterized by a variety of distinct properties
Summary
This collection is devoted to the role of extracellular adenosine 5 triphosphate (ATP) as a physiological transmitter in health and as an essential contributor to various pathologies. A further fundamental role of ATP was later identified, namely that extracellular ATP serves as a messenger for fast intercellular communications via binding to and activation of a set of membrane proteins termed P2X receptors. ATP-gated P2X receptors are expressed in neurons, glia and vascular cells and are characterized by a variety of distinct properties.
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