Abstract
Purpose: To explore the outcomes and safety of atorvastatin/trimetazidine combination therapy in patients with chronic cardiac failure.Methods: A total of 144 patients with chronic cardiac failure were divided into test group (n = 72) and control group (n = 72). In addition to conventional anti-heart failure treatment, all patients in the two groups received atorvastatin, and those in the test group received, in addition, trimetazidine, for 28 days. The clinical outcomes and safety profiles of the two groups were determined and compared.Results: Compared with pre-treatment stage, the left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), left ventricular early diastolic peak velocity (E), as well as E to left ventricular end diastolic peak velocity (A) ratio (E/A ratio) for both groups improved significantly after treatment, while A and serum brain natriuretic peptide (BNP) level decreased significantly (all p < 0.05). Moreover, compared with control group, the increases in LVEF, LVFS, E, and E/A ratio of the test group were greater (42.81 ± 3.04 vs 47.97 ± 4.22 %; 31.01 ± 3.19 vs 36.02 ± 3.31 %; 57.44 ± 5.18 vs 61.93 ± 5.42 cm/s; 1.02 ± 0.06 vs 1.19 ± 0.11, respectively), while the decreases in A and BNP level were greater (both p < 0.05) (57.34 ± 4.70 vs 52.37 ± 3.17 cm/s; 589.73 ± 41.19 vs 498.65 ± 30.89 pg/mL, respectively). Therapeutic outcomes were significantly better in the test group than in control group (p < 0.05). Blood pressure, heart rate and serum levels of alanine transaminase (ALT) and creatinine did not differ significantly between the two groups (p > 0.05), but serum potassium and aspartate amino transferase levels were lower in the test group than in the control group (p < 0.05).Conclusion: Atorvastatin combined with trimetazidine effectively reduces BNP level and improves cardiac function in patients with cardiac failure. The safety profile of the combined therapy is good.Keywords: Atorvastatin, Trimetazidine, Chronic cardiac failure, Combination therapy, Biochemical profile
Highlights
Chronic cardiac failure refers to cardiac systolic and/or diastolic functional insufficiency caused by various heart diseases; the cardiac output does not satisfy the metabolic demand
We explored the outcomes of combined atorvastatin/trimetazidine therapy in patients who received conventional antiheart failure treatment; we sought to provide a practical and theoretical basis for clinical combination therapy
The decrease in the brain natriuretic peptide (BNP) level was greater in the test group (498.65 ± 30.89 pg/mL) than the control group (589.73 ± 41.19 pg/mL, t = 13.793, p = 0.000)
Summary
Chronic cardiac failure refers to cardiac systolic and/or diastolic functional insufficiency caused by various heart diseases; the cardiac output does not satisfy the metabolic demand. The incidence of chronic cardiac failure has increased annually, and the fatality rate over the last five years has attained 50 % [3] Such patients are unable to output all returning blood, reducing the stroke volume, causing pulmonary venous stasis and even acute pulmonary oedema. All met the chronic cardiac failure criteria of the New York Heart Association (NYHA) We excluded those who had undergone any other treatment during the prior 3 months and those diagnosed with acute myocardial infarction, a tumor, another organic lesion, hypotension, anaemia, or serum creatinine and potassium levels > 252.2 μmol·L-1 and > 5.5 mmol·L-1, respectively. Treatment was considered significantly effective if cardiac function improved by two or more grades; palpitations, anhelation, or dyspnoea disappeared or were significantly relieved; lung rales or crepitations disappeared or were reduced; heart rate normalized; and/or the electrocardiogram findings improved. A pvalue < 0.05 was considered to reflect statistical significance
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
