Abstract
Background Lipopolysaccharide (LPS) exposure in early life is associated with a lower incidence of atopy. We sought to determine whether atopy regulates TLR-4 expression and LPS-induced signal transduction on peripheral immune cells e.g. CD4 T ‘helper’ T cells, monocytes and B cells of a large pediatric cohort.
Highlights
Lipopolysaccharide (LPS) exposure in early life is associated with a lower incidence of atopy
Non-atopic monocytes prominently internalize TLR-4 and trigger signal transduction upon LPS exposure. Such LPS responsiveness was strikingly impaired in monocytes from atopic children
In T cells, TLR-4 expression varies with age and atopy; atopic children display reduced
Summary
Lipopolysaccharide (LPS) exposure in early life is associated with a lower incidence of atopy. We sought to determine whether atopy regulates TLR-4 expression and LPS-induced signal transduction on peripheral immune cells e.g. CD4 T ‘helper’ T cells, monocytes and B cells of a large pediatric cohort
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