Atopik Dermatit ve Kronik Spontan Ürtikerde Hastalık Aktivite Skoru, Serum Parametreleri ve Deri Prick Testi Arasındaki İlişkinin Araştırılması: Kesitsel Çalışma

Abstract

Objective: Atopic dermatitis and chronic spontaneous urticaria are allergic skin diseases with recurrent attacks. In this study, disease activity score and laboratory parameters were investigated in patients with atopic dermatitis and chronic spontaneous urticaria. Material and Methods: A total of 68 patients including 33 atopic dermatitis and 35 chronic spontaneous urticaria patients from the dermatology outpatient clinics were enrolled in this study. Serum levels of total immunoglobulin E (IgE), blood eosinophil and basophil counts; prevalence of sensitization to aeroallergens, and disease activity scores were compared between the two groups. Results: A higher eosinophil count in the peripheral blood was observed in atopic dermatitis patients compared to chronic spontaneous urticaria patients. Disease activity scores (SCORAD index) were positively correlated with the eosinophil count and total IgE levels. Furthermore, it was found that the basophil count increased while total IgE levels and SCORAD index scores decreased in the chronic period of the disease. Total IgE levels and SCORAD index scores were higher in atopic dermatitis patients with a positive skin prick test. In chronic spontaneous urticaria patients, it was observed that basophil counts and total IgE levels were correlated, but there was not a correlation between disease activity scores, skin prick test results, and levels of other laboratory parameters. Conclusion: The relationship of serum parameters, especially IgE levels, with the disease activity was found to be significant only in atopic dermatitis.