Abstract
HA Brough, AH Liu, S Sicherer. J Allergy Clin Immunol. 2014;135(1):164–170 To evaluate whether environmental peanut exposure is a risk for peanut sensitization and allergy and whether this risk is modified by an impaired skin barrier. Subjects were 359 atopic children, aged 3 to 15 months, who had been recruited to the National Institutes of Health-sponsored Consortium of Food Allergy Research (CoFAR) Observational Study and had dust samples available for analysis. Participants had a clinical history of cow’s milk and/or egg allergy with a positive skin prick test (SPT) to these allergens or had moderate to severe atopic dermatitis and a positive SPT and with no …
Highlights
History and severity of atopic dermatitis (AD) are risk factors for peanut allergy
There was a trend toward an association between EPE and peanut allergy (PA) on univariate analysis (n 5 209; odds ratios (ORs), 1.46; 95% CI, 0.92-2.29; P 5 .11) and a significant association on multivariate logistic regression (LR) analysis (n 5 209; OR, 2.10; 95% CI, 1.20-3.67; P < .01), adjusting for ethnicity, egg skin prick test (SPT) wheal diameter, and cow’s milk SPT wheal diameter
There was a significant interaction between EPE and AD on the risk of peanut SPT sensitization (OR, 1.41; 95% CI, 1.01-1.97; P < .05) per log[2] unit EPE increase; this further increased when comparing the interaction between EPE and a history of severe AD (OR, 1.46; 95% CI, 1.04-2.07; P < .05)
Summary
History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to food allergens through an impaired skin barrier. Household peanut consumption, which correlates strongly with peanut protein levels in household dust, is a risk factor for peanut allergy. Objective: We sought to assess whether environmental peanut exposure (EPE) is a risk for peanut sensitization and allergy and whether markers of an impaired skin barrier modify this risk
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