Abstract
Progress in laboratory diagnostics of IgE-mediated allergies is being made through the use of component-resolved diagnosis. The aim of our study is to analyze the sensitization profile to allergen reagents in patients suffering from atopic dermatitis with the use of the ALEX 2–Allergy Explorer and especially to show the sensitization to molecular components of molds and yeast. The complete dermatological and allergological examination including the examination of the sensitization to allergen reagents with Allergy Explorer ALEX 2 testing was performed. The relation between the sensitization to molecular components of molds and yeast and the severity of atopic dermatitis, and the occurrence of bronchial asthma and allergic rhinitis was evaluated. Altogether, 100 atopic dermatitis patients were examined—48 men and 52 women, with an average age of 40.9 years. The sensitization to Mala s 6, Mala s 11, Sac c, Asp f 6, Cla h and Cla h 8 correlates to the severity of atopic dermatitis. The sensitization to Sac c, Alt a 6, Cla h, Cla h 8 was observed significantly more frequently in patients suffering from bronchial asthma to Mala s 6 in patients suffering from allergic rhinitis. In patients with severe form of atopic dermatitis (AD), a very high level of specific IgE was recorded to Mala s 11 (in 36%) and to Asp f 6 (in 12%).
Highlights
Atopic dermatitis (AD), together with bronchial asthma and allergic rhinitis, belongs to so-called atopic diseases
The important role of patients suffering from severe form of AD play the molecular components of Aspergillus fumigatus; in these patients, a high level of specific IgE to Asp f 6 was recorded in 24% of patients, a very high level of specific IgE to Asp f 6 was recorded in 12% of patients, a moderate level of sIgE to Asp f 3 was recorded in
In patients suffering from AD, the high sensitization was recorded to Alt a 1 (Alternaria) in 26% and to Mala s 11 (Manganese superoxide dismutase, Malassezia sympodialis) in 24%
Summary
Atopic dermatitis (AD), together with bronchial asthma and allergic rhinitis, belongs to so-called atopic diseases. Atopic dermatitis is a chronic severe itchy inflammatory disease of the skin. Abnormal immune response and defective skin barrier are involved in the etiopatogenesis of the disease. Interest in the disease is constantly increasing, due to its increasing prevalence and adverse effects on quality of life [1,2,3,4,5]. Atopic dermatitis was originally considered to be mainly a childhood disease with an imbalance between the Th2 response and the escalated IgE response to external allergens. Atopic dermatitis is rated as a long-term disease with varying clinical manifestations and expressivity, with epidermal barrier disorder playing a central role [1,2,3,4,5]
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