Abstract
Choosing 7Li and 12C heavy ions respectively with differentlinear energy transfer (LET) values, purified plasmid DNA samples inaqueous solution are irradiated with various doses. The atomic forcemicroscopy (AFM) is used for analysis of DNA fragments induced by boththe kinds of heavy ions. There is a change of three forms of DNA, i.e.supercoiled, open circular and linear form, as the dose is observed.The distribution function of DNA fragment length is obtained for thefirst time and fitted with the Tsallis entropy statistical theory. Theresult indicates that AFM is a useful tool for analysis of the shortfragment of DNA, high-LET heavy ion radiation induces DNA double strandbreaks (DSBs) more effectively, and the distributions of the DSBs aremore local and dense in comparison with low-LET radiation.
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