Abstract
Simple and accurate methods are described for the quantitative determination of flufenamic acid, mefenamic acid and tranexamic acid utilizing precipitation reactions with cobalt, cadmium and manganese. The acidic drugs were precipitated from their neutral alcoholic solutions with cobalt sulphate, cadmium nitrate or manganese chloride standard solutions followed by direct determination of the ions in the precipitate or indirect determination of the ions in the filtrate by atomic absorption spectroscopy. The optimum conditions for precipitation were carefully studied. The molar ratio of the reactants was ascertained. Statistical analysis of the results compared to the results of the official methods revealed equal precision and accuracy. The suggested procedures were applied for determining flufenamic acid, mefenamic acid and tranexamic acid in pharmaceutical preperations as well and proved validity.
Highlights
Simple and accurate methods are described for the quantitative determination of flufenamic acid, mefenamic acid and tranexamic acid utilizing precipitation reactions with cobalt, cadmium and manganese
Several techniques were used for determination of flufenamic acid such as- fluorometricl, chromatographic[2] and spectrophotometricJ~o' nes
Tranexamic acid [4-(Amino methyl) cyclohexanecarboxylic acid] is an antifibrinolytic agent used mainly in the treatment and prophylaxis of haemorrhage associated with excessive fibrinolysis
Summary
Flufenamic acid is a non steroidal anti-inflammatory, antipyretic drug with analgesic properties. Several techniques were used for determination of flufenamic acid such as- fluorometricl, chromatographic[2] and spectrophotometricJ~o' nes
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