Abstract
An atmospheric pressure chemical ionization (APCI) interface was developed for improved sensitivity in semimicro liquid chromatography/mass spectrometry (LC/MS). This interface consists of a stainless-steel capillary inserted into a bored stainless-steel block, and includes a collision plate perforated by off-center holes and a needle to generate a corona discharge. Optimization of the temperature of the stainless-steel block and the internal volume in the interface increases the ionization efficiency. The sensitivity of a semimicro LC/MS system equipped with this APCI interface is more than one order of magnitude higher than that of a conventional LC/MS system equipped with the existing APCI interface. © 1997 John Wiley & Sons, Ltd.
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