Abstract
Atherosclerosis or arteries hardening was a condition wherein occurred a plaque buildup in the arteries and often related with high-cholesterol foods. Aims : The research was intended to prove the high-cholesterol feed could increase the occurrence of atherosclerosis towards rat aorta walls. Methods : The Randomized Post-test Only Control Group Design was conducted in two groups of male Wistar rats 10-12 weeks old, weight from 140 to 150 grams. Each group consisted of 10 rats, one group was fed a standard feed and the other group was fed a high-cholesterol feed. Histopathological preparations were to use Hematoxylin-eosin staining (HE). The data was analyzed by computer, with α 0.05. Results : Eighty percent of a rat who was fed a high-cholesterol feed was found a plaque in its aorta while the rat fed a standard feed only 10%. It was obtained a relationship between high cholesterol feed with the plaque formation in the rat's aortic wall ( p 0.003). Conclusion : There was a relationship between the feed provisions of high-cholesterol with the occurrence for atherosclerosis towards rat aortic.
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