Atherosclerosis Drug Discovery

Abstract

Section 1 Primate Models.- A Model for Therapeutic Interventions on Established Coronary Atherosclerosis in a Nonhuman Primate.- The Nonhuman Primates as Models for Studying Human Atherosclerosis: Studies on the Chimpanzee, the Baboon and the Rhesus Macacus.- Phylogenetic Variability of Serum Lipids and Lipoproteins in Nonhuman Primates Fed Diets with Different Contents of Dietary Cholesterol.- The Baboon in Atherosclerosis Research: Comparison with Other Species and Use in Testing Drugs Affecting Lipid Metabolism.- The Fine Structure of Nonatherosclerotic Intimal Thickening, of Developing, and of Regressing Atherosclerotic Lesions at the Bifurcation of the Left Coronary Artery.- Apo-Lipoprotein Localization in Human Atherosclerotic Arteries.- Section 2 Rabbit Models.- Rabbits as a Model for the Study of Hyperlipoproteinemia and Atherosclerosis.- Seasonal Variations in Severity of Experimental Atherosclerosis in Rabbits.- Study of Drugs Affecting Cholesterol-Induced Atherosclerosis in Rabbits.- Turnover and Aortic Uptake of Very Low Density Lipoproteins (VLDL) from Hypercholesteremic Rabbits as a Model for Testing Antiatherosclerotic Compounds.- Evaluation of Permeability Parameters (Influx, Efflux and Volume of Distribution) of Arterial Wall for LDL and Other Proteins.- Oxygen Diffusion and Atherosclerosis.- Section 3 Rodent Models.- High Volume Screening Procedures for Hypobetalipoproteinemic Activity in Rats.- Biological Activity of a Hypobetalipoproteinemic Agent.- Nonisotopic Method for Estimating Cholesterogenesis in the Rat.- Cholesterol Metabolism in Rats Sensitive to High Cholesterol Diet.- Importance of Sex and Estrogens in Amelioration of Lethal Circulatory Stress Reactions: Relationship to Microcirculatory and Reticuloendothelial System Function.- Inbred Mice and Their Hybrids as an Animal Model for Atherosclerosis Research.- Diet Induced Hypercholesterolemia in the Diabetic and Non-Diabetic Chinese Hamster.- Section 4 Avian Models.- Animal Model for Experimental Atherosclerosis Produced by Selective Breeding of Japanese Quail.- Morphologic Observations on Experimental Atherosclerosis in SEA Japanese Quail.- A Mechanism for Lipid Accumulation and Central Necrosis in Fibrous Plaques.- The Influence of Some Dietary Factors and/or Treadmill Exercise on Rat and Chicken Tissue Lipids and Serum Lipoproteins.- Section 5 Tissue Culture.- Effects of Cholesterol Derivatives on Sterol Biosynthesis.- Mechanism of Inhibition of Cholesterol Uptake by the Arterial Wall.- Lipoprotein Uptake and Degradation by Cultured Human Arterial Smooth Muscle Cells.- The Removal of Cellular Lipids from Landschutz Ascites Cells and Smooth Muscle Cells in Culture.