Abstract

Atherosclerosis is a systemic disease that occurs due to the formation of Fibro-fatty lesions in arteries that block blood flow. The process of Atherosclerosis is initiated through mechanical, chemical, and immunological activation of the endothelium. Even there are microorganisms involved in the different stages of atherosclerosis. There are a number of molecular factors, RNA’s, macrophages and enzymes that play a vital role in the progression and development of Atherosclerosis that alter the metabolism of Fibro-fatty. Receptors of micro RNA proliferate and regulate endothelial activation and smooth cell Macrophages, monocytes, t-cell and natural killer cells involved in the boosting of the immune system to prevent the atherosclerotic lesion formation. In this review, we can know how RNA’s involved in the pathophysiology side of atherosclerosis and explore the mechanism to regulate Atherosclerosis, and how macrophages evoke an immune response. Therefore, the use of synthetic and natural drugs and following the right diet timely prevent and reduce the risk of development of Atherosclerosis.

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