Atherogenic lipid profile in psoriasis: Correlation with severity and duration of the disease

Abstract

Background: Psoriasis has been considered of late as a dermatological disorder with systemic inflammation that could contribute to various systemic effects like atherogenic dyslipidemia. Materials and Methods: Eighty patients with psoriasis and 80 age and sex matched controls were included in the study for their serum lipid profiles. The lipid values were compared with special emphasis on the duration and severity of the disease. Results: Serum triglycerides were found to be significantly higher in the psoriasis group than in the control group ( P ≤ 0.05). No significant difference was found between serum total cholesterol, low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C) levels in the two groups. However, Low HDL-C levels were found in patients with disease of more than 2 years ( P ≤ 0.05) and elevated total cholesterol ( P P 12). Conclusion: Atherogenic dyslipidemia is observed in psoriasis, but the degree of change may vary based on the duration and severity of psoriasis. More studies with a higher sample size are required to obtain longitudinal data for conclusive evidence about the systemic effects on lipid profiles in psoriasis.