Atherogenic Index of Plasma, Triglyceride-Glucose Index and Monocyte-to-Lymphocyte Ratio for Predicting Subclinical Coronary Artery Disease

Yueqiao Si,Wenjun Fan,Chao Han,Jingyi Liu,Lixian Sun

doi:10.1016/j.amjms.2021.05.001

Yueqiao Si, Wenjun Fan + Show 3 more

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https://doi.org/10.1016/j.amjms.2021.05.001

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Abstract

BackgroundThe atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD. MethodsA total of 697 asymptomatic patients were enrolled in this study and assigned to the subclinical CAD group (n=332) and control group (n=365). The clinical data, coronary artery calcification score, and calculated AIP, TyG index, and MLR were collected by graduate students in the cardiology division. Multivariate logistic regression models were set up to assess the risk factors for subclinical CAD. ResultsThe AIP, TyG index and MLR values were higher in the subclinical CAD group than in the control group (all P<0.05). In addition to the classic independent clinical risk factors, increased AIP, TyG index and MLR values were all independent risk factors for subclinical CAD (all P<0.05). The AUCs were higher after combining clinical risk factors than the AIP, TyG index, or MLR alone (all P<0.05). ConclusionsThe AIP, TyG index and MLR are independent risk factors for subclinical CAD, which can be useful for improving the diagnosis and prevention of CAD.

Highlights

Coronary artery disease (CAD) is the leading cause of death in cardiovascular disease, and the progression of coronary atherosclerosis leads to the onset of future cardiac events and is associated with a poor prognosis[1,2]
The atherogenic index of plasma (AIP), TyG index and monocyte-tolymphocyte ratio (MLR) values were higher in the subclinical coronary artery disease (CAD) group than in the control group
The AIP, TyG index and MLR are independent risk factors for subclinical CAD, which can be useful for improving the diagnosis and prevention of CAD

Summary

Introduction

Coronary artery disease (CAD) is the leading cause of death in cardiovascular disease, and the progression of coronary atherosclerosis leads to the onset of future cardiac events and is associated with a poor prognosis[1,2]. Coronary artery calcification (CAC) is an established marker for subclinical atherosclerosis and CAD[3]. Studies have shown that the atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-to-lymphocyte ratio (MLR) are new markers for atherosclerosis, insulin resistance and inflammation, respectively[6,7,8]. We investigated the association of the AIP, TyG index, and MLR with subclinical CAD and evaluated the ability of the AIP, TyG index, and MLR to predict subclinical CAD. The atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and monocyte-tolymphocyte ratio (MLR) are strongly associated with atherogenesis of the coronary artery. This study aimed to investigate the association of the AIP, TyG index, and MLR with subclinical coronary artery disease (CAD) and evaluate their ability to predict subclinical CAD

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