Abstract
We aimed to determine the association of atherogenic index of plasma (AIP) with hyperuricemia (HUA) in the rural population of northeast China. This cross-sectional study was conducted in the rural areas of northeast China from January 2012 to August 2013, and the final analysis included data obtained form 5253 men and 6092 women. 1104 participants (9.7%) suffered from HUA. Spearman rank test showed that AIP was positively correlated with uric acid in both sexes (r = 0.310 for men and r = 0.347 for women, both p < 0.001). AIP was classified into three groups: the low (<0.11), the intermediate (0.11–0.21) and the increased (>0.21) risk. The prevalence of HUA increased with AIP. Multivariate logistic regression analysis showed that, compared to the low AIP group, participants in increased AIP group had a 2.536-fold risk for HUA (2.164-fold in male and 2.960-fold in female) after adjustment for covariates. Results of receiver operating characteristic curves showed that the area under the curve (95% confidence intervals) was 0.686 (0.665–0.707) for male and 0.730 (0.706–0.755) for female. We indicated that increased AIP was associated with higher serum uric acid levels and could be identified as an independent risk factor of HUA in the rural population of northeast China.
Highlights
Hyperuricemia (HUA) is a major public health problem that threatens human health
We indicated that increased atherogenic index of plasma (AIP) was associated with higher serum uric acid levels and could be identified as an independent risk factor of HUA in the rural population of northeast China
Participants diagnosed with HUA tended to be older and male. They had a higher value of Body mass index (BMI) and Waist circumference (WC)
Summary
Hyperuricemia (HUA) is a major public health problem that threatens human health. With the improvement of living standards, high purine, and high protein diet increase, and the prevalence of HUA has been increasing in recent decades worldwide [1,2,3,4]. Data from a national survey demonstrated that the prevalence of HUA among Chinese adults in 2009–2010 was 8.4%. The prevalence of HUA among US adults in. 2007–2008 was 21.2% in male and 21.6% in female, respectively [2]. A nationwide population-based study conducted in Italy indicated that the prevalence of HUA increased from 8.5% in 2005 to 11.9%. Data from the Bangkok population showed that 11% of females but an amazing 59%
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