Abstract
Deeply involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Whose correlation with metabolic syndrome (MetS), hypertension and type 2 diabetes mellitus (T2DM) has been well established. We conducted a 9-year longitudinal study to identify the association between easily measured lipid parameters, future MetS, hypertension and T2DM by gender and age distribution. Divided into three groups by age (young age: < 40, middle age: ≥ 40 and < 65 and old age: ≥ 65), 7670 participants, receiving standard medical inspection at Tri-Service General Hospital (TSGH) in Taiwan, had been enrolled in this study. Atherogenic index of plasma (AIP) was a logarithmically transformed ratio of triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C). Through multivariate regression analyses, the hazard ratio (HR) of AIP for MetS, hypertension and T2DM were illustrated. AIP revealed significant association with all the aforementioned diseases through the entire three models for both genders. Additionally, AIP revealed significant correlation which remained still after fully adjustment in MetS, hypertension, and T2DM groups for subjects aged 40–64-year-old. Nevertheless, for participants aged above 65-year-old, AIP only demonstrated significant association in MetS group. Our results explore the promising value of AIP to determine the high-risk subjects, especially meddle-aged ones, having MetS, hypertension, and T2DM in the present and the future.
Highlights
IntroductionCardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world
Involved with dyslipidemia, cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world
The aim of the present study was to investigate the possible contribution of Atherogenic index of plasma (AIP) to future hypertension, type 2 diabetes mellitus (T2DM), and metabolic syndrome (MetS) in Taiwan citizens between 2007 and 2015
Summary
Cardiovascular disease has becoming the leading cause of mortality since the early twentieth century in the modern world. Abbreviations AIP Atherogenic index of plasma Apo-A1 Apolipoprotein A1 Apo-B Apolipoprotein B BMI Body mass index BUN Blood urea nitrogen CREA Creatinine CVD Cardiovascular disease DBP Diastolic blood pressure EDTA Ethylenediaminetetraacetic acid HDL-C High-density lipoprotein cholesterol IL-6 Interleukin-6 LDL-C Low-density lipoprotein cholesterol MetS Metabolic syndrome. Hartopo et al.[8] demonstrated the association between major adverse cardiovascular events and the AIP value (AIP ≥ 0.24 as high AIP group; AIP < 0.24 as low AIP group) in patients suffering from acute myocardial infarction during intensive hospitalization in a prospective cohort study Their results demonstrated the role of a low instead of high AIP value as an independent predictor for all-cause mortality for their participants. A cross-sectional study in Cameroonian postmenopausal women reported that AIP failed to hold the potential of being an independent risk factor of CVD by Nansseu et al.[9]
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