Atherogenic Index of Plasma and Its Association with Risk Factors of Coronary Artery Disease and Nutrient Intake in Korean Adult Men: The 2013-2014 KNHANES.

Hye Ran Shin,Sun Yung Ly,Jin Ah Cho,Sujin Song

doi:10.3390/nu14051071

Hye Ran Shin, Sun Yung Ly + Show 2 more

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https://doi.org/10.3390/nu14051071

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Journal: Nutrients	Publication Date: Mar 3, 2022
Citations: 17	License type: CC BY 4.0

Affiliation: Chungnam National University, Hannam University

Abstract

Coronary artery disease (CAD) has been linked to one of the highest death rates globally. The atherogenic index of plasma (AIP) may be an important predictor of atherosclerosis and cardiovascular disease, superior to the standard atherosclerotic lipid profile. This study investigated the relationship between AIP and obesity indices, blood glucose, lipid profile, and nutrient intake status in Korean adult men. The study included 1292 males aged ≥19 years old who participated in the Korea National Health and Nutrition Examination Survey, 2013–2014. Participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)). Body mass index, waist circumference, fasting blood glucose, hemoglobin A1c, total cholesterol, TG, and low-density lipoprotein cholesterol levels increased as AIP levels increased, whereas HDL-C level declined. As the level of AIP increased, intake of saturated fatty acid, calcium, phosphorus, riboflavin, milk, and dairy product decreased significantly, and the contribution rate of milk and dairy products to fat intake decreased. AIP was linked to obesity indices, blood glucose, and blood lipid profile in Korean men, suggesting that it could predict CAD.

Highlights

Coronary artery disease (CAD) has a high prevalence and incidence, and it is linked to one of the highest death rates in the world [1–3]
This study aimed to investigate the association between atherogenic index of plasma (AIP) and obesity, glucose metabolism, and lipid metabolism indicators in Korean adult men and analyze nutrient and food intakes according to AIP levels using data from the Korea National Health and Nutrition Examination Survey (KNHANES), 2013–2014, the last year in which blood vitamin D levels were measured in Korea
There was no difference in residential area, occupation, education level, and dietary supplement use according to the quartile of AIP

Summary

Introduction

Coronary artery disease (CAD) has a high prevalence and incidence, and it is linked to one of the highest death rates in the world [1–3]. Serum lipid markers are major risk factors and predictors of CAD and cardiovascular disease (CVD) [2,6]. Dyslipidemia refers to abnormal levels of serum lipids (triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC)) [7,8]. In clinical trials to date, high LDL-C, TG, TC, and low HDL-C have been reported to be highly related to CVD [9,10]. There were various indices for predicting CVD, such as the TG/HDL-C ratio [11] and the atherogenic index (AI: LDL-C/HDL-C) [12]. The Atherogenic Index of Plasma (AIP) was introduced as a better marker for CAD than the conventional ratio in clinical studies [1,2,13–15]

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