ATG8-Interacting Motif: Evolution and Function in Selective Autophagy of Targeting Biological Processes.

Wanqing Liu,Zinan Liu,Zulong Mo,Shaoying Guo,Qingjun Xie,Yunfeng Liu

doi:10.3389/fpls.2021.783881

Wanqing Liu, Zinan Liu + Show 4 more

Open Access

https://doi.org/10.3389/fpls.2021.783881

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Abstract

Autophagy is an evolutionarily conserved vacuolar process functioning in the degradation of cellular components for reuse. In plants, autophagy is generally activated upon stress and its regulation is executed by numbers of AuTophaGy-related genes (ATGs), of which the ATG8 plays a dual role in both biogenesis of autophagosomes and recruitment of ATG8-interacting motif (AIM) anchored selective autophagy receptors (SARs). Such motif is either termed as AIM or ubiquitin-interacting motif (UIM), corresponding to the LC3-interacting region (LIR)/AIM docking site (LDS) or the UIM docking site (UDS) of ATG8, respectively. To date, dozens of AIM or UIM containing SARs have been characterized. However, the knowledge of these motifs is still obscured. In this review, we intend to summarize the current understanding of SAR proteins and discuss the conservation and diversification of the AIMs/UIMs, expectantly providing new insights into the evolution of them in various biological processes in plants.

Highlights

Being unable to move, plants are often confronted with adversely stressful conditions, including abiotic and biotic stress (Zhu, 2016)
It was further found that the ATG8-interacting motif (AIM) NEWEVV but not the ERWQIL in the N-terminal of Arabidopsis ATG8-interacting protein 1 (ATI1)/2 is functional since mutation of this motif could block the interaction with ATG8 (Sjøgaard et al, 2019; Figure 2)
We propose that Brassinosteroid Insensitive 2 (BIN2) indirectly participate in the regulation of autophagy

Summary

Introduction

Plants are often confronted with adversely stressful conditions, including abiotic and biotic stress (Zhu, 2016). It was further found that the AIM NEWEVV but not the ERWQIL in the N-terminal of Arabidopsis ATI1/2 is functional since mutation of this motif could block the interaction with ATG8 (Sjøgaard et al, 2019; Figure 2).

Results

Conclusion