Abstract
The online version contains supplementary material available at 10.1007/s40203-021-00076-z.
Highlights
Programmed death-1 (PD-1) is a protein expressed on the T and B lymphocytes, monocytes, natural killer T cells as well as dendritic cells
Programmed death-ligand 1 (PD-L1), called B7 homolog 1 (B7-H1), is a human protein playing an important biomarker role in highly proliferation cells which is encoded by the CD274 gene
It is necessary to mention that the precise and accurate design of the immune-therapeutic agents against cancer cells, can be confirmed by employed in-silico approach. Using this method, we have designed a capable immunotoxin targeting the PD-L1 in an accurate orientation and cause the cancer cell destruction by its toxin domain
Summary
Programmed death-1 (PD-1) is a protein expressed on the T and B lymphocytes, monocytes, natural killer T cells as well as dendritic cells. The functional interaction between PD-1 and PD-L1 inhibits T cell growth and cytokine secretion. Binding between the PD-1 and its ligand (PDL1) limits T-cell activity and prevents excessive immune stimulation. This immunological mechanism maintains the immune tolerance to self-antigens by negative regulation of the immune response [4]. Programmed death-ligand 1 (PD-L1), called B7 homolog 1 (B7-H1), is a human protein playing an important biomarker role in highly proliferation cells (like cancer cells) which is encoded by the CD274 gene. The interaction between PD-1 and PD-L1 inhibits T cell growth and cytokine secretion. PD-L1 seems to be a suitable target for designing the immune-therapeutics
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