Abstract
This study evaluates how atenolol affects dental mineralization in offspring of female spontaneously hypertensive rats (fSHR) and normotensive Wistar rats (fW). fSHR and fW were treated with atenolol (100 mg/Kg/day, orally) during pregnancy and lactation. Non-treated fSHR and fW were the control groups. Enamel and dentin hardness were analyzed (Knoop, 15 g load, 10s) in mandibular incisor teeth (IT) and molar teeth (MT) obtained from the male offspring of atenolol-treated and non-treated fWistar and fSHR. Data were analyzed by ANOVA, followed by Tukey post hoc test (p < 0.05). Atenolol reduced the arterial blood pressure (SBP) in fSHR, but it did not change the SBP in fW. The offspring of non-treated fSHR had lower enamel (IT and MT) and dentin (IT) hardness than the offspring of non-treated fW (p < 0.05). Atenolol increased enamel and dentin hardness in the IT obtained from the offspring of fSHR and fW (p<0.05), but the offspring of fSHR presented higher values (p < 0.05). Atenolol did not alter enamel width in the IT obtained from any of the groups, but it increased enamel and dentin hardness in the IT obtained from the offspring of fSHR and fW. Atenolol affected the IT obtained from the offspring of fSHR. Atenolol increased only enamel hardness in the MT obtained from the offspring of fW. In conclusion, maternal hypertension reduces tooth hard tissues, and treatment with atenolol increases tooth hardness in male offspring of hypertensive and normotensive female rats.
Highlights
ObjectivesThis study aimed to evaluate how atenolol impacts dental mineralization in male offspring of female spontaneously hypertensive rats (SHR) treated with this compound during pregnancy and lactation
Their offspring were housed in the same conditions. female spontaneously hypertensive rats (fSHR) and female normotensive Wistar rats (fW) were treated with atenolol 100 mg/Kg/day diluted in a predetermined water volume that they ingested per day
The systolic blood pressure (SBP) reduced on the 20th (139mmHg ± 9) day of pregnancy in fSHR, but the value was still higher (p < 0.05) when compared to the value measured in fW on the same day
Summary
This study aimed to evaluate how atenolol impacts dental mineralization in male offspring of female SHR treated with this compound during pregnancy and lactation
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