Asymptotic behavior of distributions of mRNA and protein levels in a model of stochastic gene expression

Abstract

The paper is devoted to a stochastic process introduced in the recent paper by Lipniacki et al. [T. Lipniacki, P. Paszek, A. Marciniak-Czochra, A.R. Brasier, M. Kimmel, Transcriptional stochasticity in gene expression, J. Theor. Biol. 238 (2006) 348–367] in modelling gene expression in eukaryotes. Starting from the full generator of the process we show that its distributions satisfy a (Fokker–Planck-type) system of partial differential equations. Then, we construct a c 0 Markov semigroup in L 1 space corresponding to this system. The main result of the paper is asymptotic stability of the involved semigroup in the set of densities.