Asymptotic analysis for a nonlinear reaction–diffusion system modeling an infectious disease

Abstract

In this paper we study a nonlinear reaction–diffusion system which models an infectious disease caused by bacteria such as those for Cholera. One of the significant features in this model is that a certain portion of the recovered human hosts may lose a lifetime immunity and could be infected again. Another important feature in the model is that the mobility for each species is allowed to be dependent upon both the location and time. With the whole population assumed to be susceptible with the bacteria, the model is a strongly coupled nonlinear reaction–diffusion system. We prove that the nonlinear system has a unique solution globally in any space dimension under some natural conditions on the model parameters and the given data. Moreover, the long-time behavior and stability analysis for the solutions are carried out rigorously. In particular, we characterize the precise conditions on variable parameters about the stability or instability of all steady-state solutions. These new results provide the answers to several open questions raised in the literature.