Asymptomatic Megaloblastic Erythropoiesis with Chromosomal Abnormalities.

Abstract

s1 May 1968Asymptomatic Megaloblastic Erythropoiesis with Chromosomal Abnormalities.Eugene P. Libre, M.D. (Associate), Jacqueline Whang, M.D., Andrew S. Tegeris, M.D.Eugene P. Libre, M.D. (Associate)Search for more papers by this author, Jacqueline Whang, M.D.Search for more papers by this author, Andrew S. Tegeris, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-68-5-1170_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA unique finding of abnormal megaloblastic erythropoiesis with marked macrocytosis (mean corpuscular volume = 127 cµ) without anemia in a healthy 50-year-old white man was documented for 16 years. During the 16-year period of observation, treatment with B12, folic acid, citrovorum factor, pyridoxine, and other hematinics did not produce any change in his marrow morphology. Serum iron, folate, B12values, Schilling test, and excretion of orotic acid were normal. There was a history of consanguinity. Asymptomatic macrocytosis was present in a brother; however, both parents, who were first cousins, and other available family members did not have macrocytosis. The propositus... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D. C. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1968Volume 68, Issue 5Page: 1170-1170KeywordsBone marrowChromosomesErythropoiesisExcretionFolic acidMean corpuscular volumeMegaloblastic anemiaPyridoxine Issue Published: 1 May 1968 PDF downloadLoading ...