Asymptomatic Inguinal Micropapules in a Patient Treated With Chemotherapy

Abstract

The patient was a 32-year-old woman diagnosed 18 months earlier with nodular sclerosing Hodgkin lymphoma, Ann Arbor stage IIIA (supradiaphragmatic and infradiaphragmatic lymph node involvement and absence of B symptoms). She had initially been treated with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine). On recurrence of the lymphoma, she was treated with 2 cycles of c-MOPP (cyclophosphamide, vincristine, prednisone, and procarbazine), which was substituted by GPD (gemcitabine, cisplatin, and dexamethasone) due to neurological toxicity (paraesthesias). It was then decided to perform autologous peripheral blood hematopoietic stem cell transplantation after conditioning with melphalan and whole-body irradiation. On day 5 after transplantation, asymptomatic skin lesions developed in both inguinal regions, initially diagnosed as candidal intertrigo. Ten days later, due to persistence of the lesions despite systemic antifungal treatment, the patient was referred to dermatology.