Abstract
High-throughput cellular imaging is acclaimed as captivating yet challenging in biomedical diagnostics. We have demonstrated a new imaging modality, <i>asymmetric-detection time-stretch optical microscopy</i> (ATOM), by incorporating a simple detection scheme which is a further advancement in time-stretch microscopy – a viable solution to achieve high-speed and high-throughput cellular imaging. Through the asymmetric-detection scheme in ATOM, the time-stretch image contrast is enhanced through accessing to the phase-gradient information. With the operation in the 1 μm wavelength range, we demonstrate high-resolution and high-contrast cellular imaging in ultrafast microfluidic flow (up to 10 m/s) by ATOM – achieving an imaging throughput equivalent to ~100,000 cells/sec.
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